October 1, 1995Circulation

Polymorphisms in the Lipoprotein Lipase Gene and Their Associations With Plasma Lipid Concentrations in 40-Year-Old Danish Men

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Why the study?

Are HindIII and Pvu II polymorphisms in the LPL gene associated with plasma lipid concentrations and risk of ischemic heart disease in 40-year-old men?

Structured PICO

Are HindIII and Pvu II polymorphisms in the LPL gene associated with plasma lipid concentrations and risk of ischemic heart disease in 40-year-old men?

Population

457 randomly selected 40-year-old Danish men

Intervention

HindIII (intron 8) and Pvu II (intron 6) restriction fragment length polymorphisms (RFLPs) in the lipoprotein lipase (LPL) gene

Comparator

Comparison between different genotypes (e.g., H+H+, H+H-, H-H-)

Outcome

Plasma concentrations of cholesterol, HDL cholesterol, non-HDL cholesterol, and triglyceridessurrogate

Genetic variation in the LPL gene (HindIII polymorphism) is associated with differences in HDL cholesterol concentrations and may influence the risk of ischemic heart disease.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

LPL HindIII variant may link to IHD risk via HDL in men; hypothesis-generating and requires prospective validation before clinical use.

Cite This Study

Gerdes et al. (1995) studied this question.

synapsesocial.com/papers/6a82c14277f6571b411e0de2 https://doi.org/10.1161/01.cir.92.7.1765

View Full Paper

Ask AI

Bookmark

Polymorphisms in the Lipoprotein Lipase Gene and Their Associations With Plasma Lipid Concentrations in 40-Year-Old Danish Men

Structured PICO

Discussion

Implication

Cite This Study

Polymorphisms in the Lipoprotein Lipase Gene and Their Associations With Plasma Lipid Concentrations in 40-Year-Old Danish Men

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider