What question did this study set out to answer?

To determine whether common lipoprotein lipase gene polymorphisms correlate with coronary artery disease severity, lipid variables, and diabetes risk.

April 1, 1996Circulation

Common DNA Polymorphisms at the Lipoprotein Lipase Gene

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Why the study?

Are lipoprotein lipase gene polymorphisms associated with coronary artery disease severity and lipid variables in white patients ≤65 years old?

Population

475 white patients 65 years of age or younger undergoing coronary angiography

Comparison

Lipoprotein lipase gene polymorphic markers vs Different genotypes (e.g., Pvu II vs Pvu II)

Design

Cross-sectional

Authors

XWX.L. WangNew South Wales Department of Health RMR. M. McCredieSingapore General Hospital DWD. E. L. WilckenPrince of Wales Hospital

Discussion

Member takes

Implication

Pvu II polymorphism may aid CAD severity assessment in younger whites; hypothesis-generating and should not yet change practice.

Key Points

To determine whether common lipoprotein lipase gene polymorphisms correlate with coronary artery disease severity, lipid variables, and diabetes risk.
Analyzed 475 white patients aged 65 years or younger undergoing coronary angiography.
Genotyped two common lipoprotein lipase gene polymorphisms (Pvu II at intron 6 and HindIII at intron 8).
Assessed coronary artery disease severity using the Green Lane coronary score and the count of major arteries with >50% luminal stenosis.
The Pvu II polymorphism significantly associated with diseased vessel count (P = .0099) and coronary score (P = .028), with Pvu II(-) alleles linking to less severe disease.
The Pvu II(+/+) genotype increased the odds of diabetes compared with Pvu II(-/-) (OR 3.12, 95% CI, 1.30 to 7.49; P = .0025), an effect independent of circulating triglycerides and HDL cholesterol levels.

Structured PICO

Are lipoprotein lipase gene polymorphisms associated with coronary artery disease severity and lipid variables in white patients ≤65 years old?

Population

475 white patients 65 years of age or younger undergoing coronary angiography

Intervention

Lipoprotein lipase gene polymorphic markers (Pvu II at intron 6 and HindIII at intron 8)

Comparator

Different genotypes (e.g., Pvu II(+/+) vs Pvu II(-/-))

Outcome

Severity of coronary artery disease (assessed as the number of significantly stenosed >50% luminal obstruction major coronary arteries at angiography and by the Green Lane coronary score)surrogate

The lipoprotein lipase Pvu II polymorphism is significantly associated with CAD severity and type II diabetes in CAD patients, independent of circulating lipid levels.

Cite This Study

Wang et al. (1996) studied this question.

synapsesocial.com/papers/6a82c0c90f52607ca18ae546 https://doi.org/10.1161/01.cir.93.7.1339

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Common DNA Polymorphisms at the Lipoprotein Lipase Gene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Common DNA Polymorphisms at the Lipoprotein Lipase Gene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider