Key result
Lipoprotein lipase and apolipoprotein E polymorphisms, along with apoE concentration, explained 42.31% and 53.62% of the total variability in triglyceride levels in women and men, respectively.
Why the study?
How do lipoprotein lipase and apolipoprotein E polymorphisms affect lipid and lipoprotein levels in healthy subjects?
Cohort (n=1,101)
How do lipoprotein lipase and apolipoprotein E polymorphisms affect lipid and lipoprotein levels in healthy subjects?
Answers are grounded in this paper and cite their sources.
ApoE and LPL genes simultaneously modulate triglyceride levels, explaining a significant portion of their variability in healthy subjects.
We have genotyped 1101 supposedly healthy subjects from the Stanislas cohort for the lipoprotein lipase (LPL) gene Ser417(C)-->stop (G) polymorphism and/or for the apolipoprotein (apo)E common polymorphism. Genotypic effects of the two polymorphisms on fasting serum triglycerides (TG), total cholesterol (Tchol), high density lipoprotein-cholesterol (HDLc), low density lipoprotein-cholesterol (LDLc), apoB, apoA-I, and apoE levels were studied separately for each polymorphism and in conjunction. epsilon 4 allele and high apoE levels were associated with high levels of LDLc, Tchol, apoB, and TG. The G allele of LPL was significantly associated with low TG levels. We found a clear interaction between the LPL/apoE polymorphisms and apoE levels on serum TG variation. Total variability of TG levels in women and men of 42.31% and 53.62% respectively, were mainly explained by apoE concentration and these two polymorphisms. ApoE and LPL genes simultaneously modulated TG levels.
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Salah et al. (1997) conducted a cohort in Healthy subjects (n=1,101). Lipoprotein lipase (LPL) and apolipoprotein (apo)E polymorphisms was evaluated on Fasting serum lipid and lipoprotein levels. Lipoprotein lipase and apolipoprotein E polymorphisms, along with apoE concentration, explained 42.31% and 53.62% of the total variability in triglyceride levels in women and men, respectively.
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