Key result
In healthy pregnant women, carriers of the LPL S447X polymorphism had significantly lower triglyceride levels (p=0.003) compared to non-carriers.
Why the study?
Do LPL and apo E polymorphisms affect lipid levels in healthy women during the 3rd trimester of pregnancy?
Population
250 healthy women in the 3rd trimester of pregnancy
Comparison
Presence of lipoprotein lipase polymorphisms and… vs Non-carriers or reference genotypes (e.g., E3/E3)
Design
Cross-sectional
Authors
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LPL S447X may influence late-pregnancy triglycerides; hypothesis-generating and should not yet change clinical practice.
Cross-Sectional (n=250)
Do LPL and apo E polymorphisms affect lipid levels in healthy women during the 3rd trimester of pregnancy?
p-value: p=0.003
LPL and apo E polymorphisms significantly influence lipid metabolism and triglyceride levels during the third trimester of pregnancy.
Sandra H. McGladdery (2009) conducted a cross-sectional in Pregnancy (n=250). LPL and apo E polymorphisms vs. Non-carriers / E3/E3 genotype was evaluated on Lipid levels (TG, TC, HDL-C, LDL-C) (p=0.003). In healthy pregnant women, carriers of the LPL S447X polymorphism had significantly lower triglyceride levels (p=0.003) compared to non-carriers.
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