Key result
LPL S447X carriers had lower triglycerides (P=0.003), N291S carriers had lower HDL-C (P<0.02), and the apoE E2 allele was associated with lower TC and LDL-C (P<0.05) during the third trimester.
Why the study?
Do LPL and apoE polymorphisms affect fasting plasma lipid levels in women during the third trimester of pregnancy?
Population
250 women in the third trimester of pregnancy
Comparison
Presence of LPL polymorphisms and apoE genotypes vs Noncarriers of LPL polymorphisms and E3/E3 apoE…
Design
Cross-sectional
Authors
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These cross-sectional associations are hypothesis-generating; leaves open whether LPL and apoE variants alter third-trimester lipids or outcomes.
Cross-Sectional (n=250)
Do LPL and apoE polymorphisms affect fasting plasma lipid levels in women during the third trimester of pregnancy?
p-value: p=0.003
LPL and apoE polymorphisms significantly influence lipid metabolism during pregnancy, contributing to variations in triglycerides, cholesterol, and HDL particle size.
McGladdery et al. (2001) conducted a cross-sectional in Hypertriglyceridemia during pregnancy (n=250). LPL and apoE polymorphisms (S447X, N291S, E2 allele) vs. Noncarriers and E3/E3 genotype was evaluated on Fasting plasma lipids (TG, TC, LDL-C, HDL-C, FER(HDL)) (p=0.003). LPL S447X carriers had lower triglycerides (P=0.003), N291S carriers had lower HDL-C (P<0.02), and the apoE E2 allele was associated with lower TC and LDL-C (P<0.05) during the third trimester.
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