Key result
Increased epicardial adipose tissue thickness was independently associated with a greater extent of aortic dissection (B = 7.32, p = 0.001).
Why the study?
Bioactive molecules from epicardial adipose tissue may affect aortic dissection propagation and extent through endothelial dysfunction and inflammatory responses, but the association between EAT thickness and aortic dissection extent was unknown.
Is epicardial adipose tissue thickness associated with the extent of aortic dissection in patients with diagnosed aortic dissection?
Cohort (n=78)
No
Is epicardial adipose tissue thickness associated with the extent of aortic dissection in patients with diagnosed aortic dissection?
Increased epicardial adipose tissue thickness is independently associated with a greater extent of aortic dissection, suggesting a potential pathophysiological link between local adiposity and dissection propagation.
Answers are grounded in this paper and cite their sources.
EAT thickness was associated with dissection extent in this cohort; hypothesis-generating, prospective studies needed before clinical consideration.
BACKGROUND: Epicardial adipose tissue (EAT) is a biologically active organ that has endocrine and paracrine functions. Endothelial dysfunction, systemic, and local inflammatory response, due to bio-active molecules produced by EAT, may affect aortic dissection propagation and extent. We investigated the association between EAT thickness and the extent of aortic dissection. METHODS: We retrospectively enrolled 78 patients with aortic dissection diagnosed by thoracoabdominal Computerized Tomography (CT). EAT was measured from the thickest part of the perpendicular plane between the pericardium and free wall of the right ventricle using CT. Aortic dissection length was measured from the beginning to the end of the dissection flap at sagittal images. RESULTS: 0.005). Multivariate analysis identified age and EAT as independent predictors of dissection length. CONCLUSION: Increased EAT was independently associated with the extent of aortic dissection. We think that either paracrine and endocrine functions of EAT might have contributed to the extent of aortic dissection.
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Ahmet S Yõlmaz (2020) conducted a cohort in Aortic dissection (n=78). Epicardial adipose tissue thickness was evaluated on Aortic dissection length (B = 7.32, 95% CI 2.993-11.66, p=0.001). Increased epicardial adipose tissue thickness was independently associated with a greater extent of aortic dissection (B = 7.32, p = 0.001).
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