Key result
EVAR experiments in a novel hydrogel-based anthropomorphic mockup revealed substantial displacements of aortic centerlines and vessel expansion when surrounding fat was absent.
Why the study?
Failures of abdominal aortic aneurysm endovascular repair reflect inadequate knowledge regarding the complex interaction between the aortic wall and medical devices.
The development of a realistic hydrogel-based AAA mockup demonstrates that surrounding fat provides an essential framework that significantly affects aortic deformation during EVAR.
Fat constrains aortic deformation in EVAR mockups; leaves open its clinical impact and requires in vivo validation.
Abdominal aortic aneurysm (AAA) is an asymptomatic condition due to the dilation of abdominal aorta along with progressive wall degeneration, where rupture of AAA is life-threatening. Failures of AAA endovascular repair (EVAR) reflect our inadequate knowledge about the complex interaction between the aortic wall and medical devices. In this regard, we are presenting a hydrogel-based anthropomorphic mockup (AMM) to better understand the biomechanical constraints during EVAR. By adjusting the cryogenic treatments, we tailored the hydrogel to mimic the mechanical behavior of human AAA wall, thrombus and abdominal fat. A specific molding sequence and a pressurizing system were designed to reproduce the geometrical and diseased characteristics of AAA. A mechanically, anatomically and pathologically realistic AMM for AAA was developed for the first time, EVAR experiments were then performed with and without the surrounding fat. Substantial displacements of the aortic centerlines and vessel expansion were observed in the case without surrounding fat, revealing an essential framework created by the surrounding fat to account for the interactions with medical devices. In conclusion, the importance to consider surrounding tissue for the global deformation of AAA during EVAR was highlighted. Furthermore, potential use of this AMM for medical training was also suggested.
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He et al. (2020) studied Abdominal aortic aneurysm (AAA). EVAR experiments in an anthropomorphic mockup with surrounding fat vs. EVAR experiments without surrounding fat was evaluated on Displacements of the aortic centerlines and vessel expansion. EVAR experiments in a novel hydrogel-based anthropomorphic mockup revealed substantial displacements of aortic centerlines and vessel expansion when surrounding fat was absent.
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