Key result
In Angiotensin II-infused mice, obesity (ob/ob genotype) significantly increased the incidence of abdominal aortic aneurysms compared to lean controls (76% vs 32%, P<0.05).
Why the study?
Does obesity promote Angiotensin II-induced abdominal aortic aneurysm formation in mice?
Population
Male C57BL/6 mice fed a high-fat (HF) diet for 1, 2, or 4 months, and ob/ob mice
Comparison
Angiotensin II infusion for 28 days vs Lean control mice infused with AngII
Design
Preclinical
Follow-up
28 days
Authors
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Obesity may enhance AngII-induced AAA via macrophage infiltration in mice; leaves open human translational relevance.
Does obesity promote Angiotensin II-induced abdominal aortic aneurysm formation in mice?
Absolute Event Rate: 76% vs 32%
p-value: p=<0.05
Obesity promotes macrophage accumulation in periaortic adipose tissue and enhances Angiotensin II-induced abdominal aortic aneurysm formation in a mouse model.
Police et al. (2009) studied Abdominal aortic aneurysm. Obesity (high-fat diet or ob/ob genotype) with Angiotensin II infusion vs. Lean controls was evaluated on Abdominal aortic aneurysm (AAA) incidence (p=<0.05). In Angiotensin II-infused mice, obesity (ob/ob genotype) significantly increased the incidence of abdominal aortic aneurysms compared to lean controls (76% vs 32%, P<0.05).
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