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December 15, 2003Journal of Clinical InvestigationOpen Access

Obesity is associated with macrophage accumulation in adipose tissue

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Population

Mice with varying adiposity due to sex, diet, and obesity-related mutations, macrophage-deficient mice, and…

Design

Preclinical

Authors

SWStuart P. WeisbergAlbert Einstein College of MedicineDMDaniel McCannNewYork–Presbyterian HospitalMDManisha DesaiGeneral Cardiology

Discussion

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Implication

Adipose macrophage accumulation may fuel obesity-related inflammation; hypothesis-generating for targeted therapies in humans.

Structured PICO

P
Population
Mice with varying adiposity due to sex, diet, and obesity-related mutations (agouti Ay and obese Lepob), macrophage-deficient (Csf1op/op) mice, and human subcutaneous adipose tissue samples.
O
Outcome
Correlation between transcript expression/macrophage markers and body mass/adipocyte sizesurrogate

Adipose tissue macrophage numbers increase in obesity and are a primary source of inflammatory cytokines like TNF-alpha, contributing to obesity-associated complications.

Cite This Study

Weisberg et al. (2003) studied this question.

synapsesocial.com/papers/69d8d22b33ca018b39ae41f6https://doi.org/10.1172/jci19246
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Also Consider

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