Key result
A single preoperative dose of dexamethasone mitigated early inflammation, lowered early pain scores, and enhanced recovery in older adults after lumbar spine surgery.
Why the study?
Does a single preoperative dose of dexamethasone improve recovery outcomes and attenuate inflammatory markers in elderly patients undergoing open lumbar surgery?
Does a single preoperative dose of dexamethasone improve recovery outcomes and attenuate inflammatory markers in elderly patients undergoing open lumbar surgery?
A single preoperative dose of dexamethasone mitigates early inflammation and enhances recovery in older adults after lumbar spine surgery.
May support preoperative dexamethasone for early recovery after lumbar spine surgery; hypothesis-generating, needs RCTs before practice change.
< 0.001; median difference 52.5 mL, 95% CI 32.5-80.0). Patients receiving dexamethasone showed lower early pain scores, improved recovery, and attenuated inflammatory markers. Transient postoperative hyperglycemia occurred without an increase in infections. These findings support a single preoperative dose of dexamethasone mitigated early inflammation and enhanced recovery in older adults after lumbar spine surgery.
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Zhang et al. (2025) studied Open lumbar surgery. Dexamethasone was evaluated (median difference 52.5 mL, 95% CI 32.5-80.0, p=< 0.001). A single preoperative dose of dexamethasone mitigated early inflammation, lowered early pain scores, and enhanced recovery in older adults after lumbar spine surgery.
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