Key result
Dexmedetomidine infusion reduced the induction dose of propofol and decreased the end-tidal concentration of isoflurane requirement by 30% during laparoscopic surgery.
Why the study?
Does dexmedetomidine as an anesthetic adjuvant reduce the requirement of anesthetics in patients undergoing laparoscopic surgery?
RCT (n=60)
Randomly allocated
Does dexmedetomidine as an anesthetic adjuvant reduce the requirement of anesthetics in patients undergoing laparoscopic surgery?
Dexmedetomidine is an effective anesthetic adjuvant that significantly reduces the requirement for propofol and isoflurane during laparoscopic surgery.
Supports dexmedetomidine to minimize anesthetic doses in laparoscopic surgery; extends RCT evidence for its adjuvant role.
Dexmedetomidine is a highly selective agonist with properties of sedation, analgesia and anxiolysis, making it an ideal anesthetic adjuvant. Using an anesthetic adjuvant decreases the requirement of anesthetics and analgesics. We studied 60 patients of ASA grade I and II, aged between 18 to 50 years, of either gender posted for laparoscopic surgeries under general anesthesia. Patients were randomly allocated in one of the two parallel groups containing 30 patients each. Group D received Dexmedetomidine infusion at the rate of 1 mcg/kg for 20 minutes and then maintenance infusion of 0.2 mcg/kg/min till extubation. Control group NS received normal saline. Induction with propofol and fentanyl was carried out. Patients were monitored with standard monitoring. A reduction in the induction dose of propofol was observed, with a 30% less end-tidal concentration of isoflurane requirement for maintenance of anesthesia. Dexmedetomidine a highly selective alpha 2 agonist is an effective anesthetic adjuvant that can be safely used in laparoscopy.
No takes yet. Share an insight, caveat, or question.
Waindeskar et al. (2015) conducted an RCT in Laparoscopic surgery (n=60). Dexmedetomidine vs. Normal saline was evaluated on Induction dose of propofol and end-tidal concentration of isoflurane requirement. Dexmedetomidine infusion reduced the induction dose of propofol and decreased the end-tidal concentration of isoflurane requirement by 30% during laparoscopic surgery.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: