Key result
Neutralizing Thrombopoietin (Tpo) eliminates megakaryocyte formation in response to c-kit ligand, IL-6, and IL-11, and prevents full maturation of IL-3-induced megakaryocytes.
Population
Megakaryocyte progenitors / hematopoietic progenitors
Comparison
Neutralization of the biological activity of… vs Presence of Tpo and other cytokines
Design
Preclinical
Authors
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Tpo neutralization may impair megakaryopoiesis driven by multiple cytokines; leaves open therapeutic targeting in thrombopoietic disorders.
Thrombopoietin is the primary regulator essential for full megakaryocyte development and platelet production.
Kaushansky et al. (1995) studied Megakaryocyte development. Neutralizing Thrombopoietin (Tpo) vs. Cytokines alone (c-kit ligand, IL-6, IL-11, IL-3) was evaluated on Megakaryocyte formation and maturation. Neutralizing Thrombopoietin (Tpo) eliminates megakaryocyte formation in response to c-kit ligand, IL-6, and IL-11, and prevents full maturation of IL-3-induced megakaryocytes.
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