Key result
Stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence in heterogeneous active media.
Why the study?
Synchronization of activity among myocytes is crucial for physiological functions, making self-organized coordination in heterogeneous ensembles of excitable and oscillatory cells clinically important.
Mechanical deformation via stretch-activated currents promotes robust global coherence in heterogeneous ensembles of excitable cells like myocytes.
Model results on myocyte synchronization are hypothesis-generating; leaves open stretch-activated current effects on cardiac arrhythmias.
Synchronization of activity among myocytes constituting vital organs, e.g., the heart, is crucial for physiological functions. Self-organized coordination in such heterogeneous ensemble of excitable and oscillatory cells is therefore of clinical importance. We show by varying the strength of intercellular coupling and the electrophysiological diversity, a wide range of collective behavior emerges including clusters of synchronized activity. Strikingly, stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence.
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Zimik et al. (2025) studied Myocyte synchronization. Stretch-activated currents and mechanical deformation was evaluated on Global coherence and synchronized activity. Stretch-activated currents allow waves of mechanical deformation to alter the activity of neighboring cells, promoting robust global coherence in heterogeneous active media.
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