A baseline resting heart rate ≥80 bpm predicted the development of obesity, diabetes mellitus, and insulin resistance over 20 years in a general population.
Cohort (n=614)
Does a higher resting heart rate predict the development of obesity and diabetes mellitus in a general population?
A higher resting heart rate is an independent predictor for the long-term development of obesity and diabetes mellitus, suggesting a role for sympathetic activation in metabolic disease.
BACKGROUND: Emerging evidence indicates an association between sympathetic activation and metabolic syndrome. However, sympathetic activation in metabolic syndrome may be a cause, consequence, or just epiphenomenon. To elucidate this issue, the predictive power of resting heart rate for the development of abnormal glucose and lipid metabolisms after 20 years was evaluated in a general population. METHODS: A total of 637 participants (>20 years old) underwent a health examination in 1979 including measurements of blood chemistries. Resting heart rate (bpm) was measured by an electrocardiogram. In 1999, all of the study participants again underwent a health examination, including electrocardiogram and blood chemistries. Because four of them had atrial fibrillation, and 19 subjects were taking antihypertensive medication in 1979, they were excluded from analysis. Therefore, a complete dataset of 614 subjects was available. RESULTS: As was reported in our previous article, in 1999 we found a linear and significant (P or=80 bpm in 1979) predicted the development of obesity, diabetes mellitus (DM), and insulin resistance in 1999 after adjustments for age, sex, and other confounders. CONCLUSION: This is one of the first prospective reports demonstrating that higher heart rate may predispose to the development of obesity and DM, suggesting that the sympathetic nerve system may play a role in the development of obesity and DM.
Shigetoh et al. (Sat,) conducted a cohort in General population (n=614). Higher resting heart rate (≥80 bpm) vs. Lower resting heart rate (<80 bpm) was evaluated on Development of obesity, diabetes mellitus, and insulin resistance. A baseline resting heart rate ≥80 bpm predicted the development of obesity, diabetes mellitus, and insulin resistance over 20 years in a general population.