Key result
Time in range assessed by continuous glucose monitoring was significantly associated with sudomotor dysfunction in patients with type 2 diabetes (P<0.001).
Why the study?
Time in range has robust relevance with diabetic complications, and the study aimed to explore its relationship with sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes.
Is time-in-range (TIR) derived from continuous glucose monitoring associated with sudomotor dysfunction in patients with type 2 diabetes?
Cross-Sectional (n=466)
Is time-in-range (TIR) derived from continuous glucose monitoring associated with sudomotor dysfunction in patients with type 2 diabetes?
Tight glycemic control, as assessed by time-in-range on continuous glucose monitoring, is associated with a lower risk of sudomotor dysfunction in type 2 diabetes.
TIR may aid sudomotor dysfunction risk stratification in T2D; leaves open whether improving TIR prevents neuropathy.
BACKGROUND: Time in range (TIR), as a novel metric for glycemic control, has robust relevance with diabetic complications. Diabetic peripheral neuropathy (DPN) is characterized by sudomotor dysfunction. AIM: To explore the relationship between TIR obtained from continuous glucose monitoring (CGM) and sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes. METHODS: The research enrolled 466 inpatients with type 2 diabetes. All subjects underwent 3-d CGM and SUDOSCAN. SUDOSCAN was assessed with electrochemical skin conductance in hands (HESC) and feet (FESC). Average feet ESC < 60 µS was defined as sudomotor dysfunction (+), otherwise it was sudomotor dysfunction (-). TIR refers to the percentage of time when blood glucose is between 3.9-10 mmol/L during 1 d period. CONCLUSION: The tight glycemic control assessed by TIR is of vitally protective value for sudomotor dysfunction in type 2 diabetes mellitus.
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Guo et al. (2020) conducted a cross-sectional in type 2 diabetes (n=466). Time in range (TIR) was evaluated on sudomotor dysfunction (Average feet ESC < 60 µS) (p=<0.001). Time in range assessed by continuous glucose monitoring was significantly associated with sudomotor dysfunction in patients with type 2 diabetes (P<0.001).
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