Key result
Postmortem blood levels of cardiac troponins T and I were significantly higher in sudden cardiac death cases compared to controls (p < 0.05).
Why the study?
Are postmortem blood biomarker levels (CK-MB, myoglobin, troponins, LDH) useful in diagnosing sudden cardiac death?
Case-Control (n=28)
Are postmortem blood biomarker levels (CK-MB, myoglobin, troponins, LDH) useful in diagnosing sudden cardiac death?
p-value: p=< 0.05
Postmortem blood troponin levels (cTn-I and cTn-T) measured within 8 hours of death may be useful to support a diagnosis of sudden cardiac death.
Postmortem troponin elevation may support sudden cardiac death diagnosis; leaves open prospective validation before routine use.
In the daily practice of forensic pathology, sudden cardiac death (SCD) is a diagnostic challenge. Our aim was to determine the usefulness of blood biomarkers [creatine kinase CK-MB, myoglobin, troponins I and T (cTn-I and T), and lactate dehydrogenase] measured by immunoassay technique, in the postmortem diagnosis of SCD. Two groups were compared, 20 corpses with SCD and 8 controls. Statistical significance was determined by variance analysis procedures, with a post hoc Tukey multiple range test for comparison of means (p < 0.05). SCD cases showed significantly higher levels (p < 0.05) of cTn-T and cTn-I compared to the control group. Although only cases within the first 8 h of postmortem interval were included, and the control group consisted mainly of violent death cases, our results suggest that blood troponin levels may be useful to support a diagnosis of SCD.
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Carvajal‐Zarrabal et al. (2017) conducted a case-control in Sudden cardiac death (n=28). Sudden cardiac death vs. Controls (mainly violent death cases) was evaluated on Postmortem blood levels of cTn-T and cTn-I (p=< 0.05). Postmortem blood levels of cardiac troponins T and I were significantly higher in sudden cardiac death cases compared to controls (p < 0.05).
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