Key result
Diabetic symmetrical polyneuropathy significantly reduced the odds of a successful elicited nociceptive withdrawal reflex compared with healthy controls (OR 0.045; P=0.014).
Why the study?
Comprehensive evaluation of upstream sensory processing in diabetic symmetrical polyneuropathy is sparse.
Does diabetic symmetrical polyneuropathy alter spinal and supraspinal sensory-motor processing compared with healthy controls?
Case-Control (n=69)
Does diabetic symmetrical polyneuropathy alter spinal and supraspinal sensory-motor processing compared with healthy controls?
Odds Ratio: 0.045
p-value: p=0.014
Type 1 diabetes patients with DSPN exhibit significantly altered spinal and supraspinal processing of somatosensory input, indicating widespread central nervous system differences.
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DSPN may reduce nociceptive withdrawal reflex success; leaves open central sensory-motor processing alterations in diabetes.
Nedergaard et al. (2020) conducted a case-control in Type 1 diabetes with diabetic symmetrical polyneuropathy (n=69). Diabetic symmetrical polyneuropathy vs. Healthy controls was evaluated on Successful elicited nociceptive withdrawal reflex (OR 0.045, p=0.014). Diabetic symmetrical polyneuropathy significantly reduced the odds of a successful elicited nociceptive withdrawal reflex compared with healthy controls (OR 0.045; P=0.014).
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