Key result
Src and Akt cooperate to regulate the association of endothelial nitric-oxide synthase with the GIT1 scaffold, facilitating nitric oxide production in response to endothelin-1.
Population
Sinusoidal endothelial cells (preclinical model)
Design
Preclinical
Authors
Loading...
Novel ETB-eNOS coupling in sinusoids extends hepatic vascular biology; leaves open therapeutic targeting in portal hypertension.
This study elucidates a molecular model in which Src and Akt cooperate to regulate eNOS association with the GIT1 scaffold, facilitating nitric oxide production in endothelial cells.
Liu et al. (2014) studied this question. Src and Akt cooperate to regulate the association of endothelial nitric-oxide synthase with the GIT1 scaffold, facilitating nitric oxide production in response to endothelin-1.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: