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June 17, 2010American Journal of Respiratory and Critical Care Medicine

Mesenchymal Stem Cells Reduce Inflammation while Enhancing Bacterial Clearance and Improving Survival in Sepsis

Shirley H. J. Mei Jack J. Haitsma Claúdia C. dos Santos Yupu Deng Patrick F.H. Lai Arthur S. Slutsky W. Conrad Liles Duncan J. Stewart

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Key Points

This study aims to investigate the effects of mesenchymal stem cells (MSCs) on inflammation and survival in a model of sepsis.
Induction of sepsis in C57Bl/6J mice via cecal ligation and puncture (CLP).
Administration of MSCs or saline 6 hours post-CLP followed by analysis at 28 hours.
Longer-term survival studies conducted with antibiotic coadministration.
MSC treatment significantly reduced mortality in septic mice receiving antimicrobial therapy.
MSC treatment lowered systemic and pulmonary cytokine levels, preventing acute lung injury.
Bacterial clearance was significantly enhanced in MSC-treated mice, linked to increased phagocytotic activity.

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Implication

Demonstrates MSCs reduce inflammation and enhance bacterial clearance in sepsis, indicating potential for improved treatment strategies.

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Cite This Study

Mei et al. (2010) studied this question.

synapsesocial.com/papers/6a6b633a2ef98b0efacb5564 https://doi.org/10.1164/rccm.201001-0010oc

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