Key result
Among 264 children hospitalized with severe acute respiratory infection, human adenoviruses and rhinoviruses were detected in 13.6% and 10.6% of cases, respectively.
Why the study?
Human rhinoviruses and human adenoviruses are prevalent in hospitalized patients with SARI, prompting evaluation of their molecular characterization in hospitalized patients aged ≤ 18 years in Tehran, Iran.
What is the prevalence and molecular characterization of HRV and HAdV in hospitalized children with SARI in Iran?
Cross-Sectional (n=264)
What is the prevalence and molecular characterization of HRV and HAdV in hospitalized children with SARI in Iran?
HRV and HAdV are prevalent in children hospitalized with SARI in Iran, with specific genotypes potentially causing more severe disease.
Supports regional SARI surveillance in children; leaves open genotype-severity links and broader applicability.
Background and Objectives: Human rhinoviruses (HRVs) and human adenoviruses (HAdVs) are among the most prevalent viruses in hospitalized patients with severe acute respiratory infection (SARI). This study aimed to evaluate the molecular characterization of HRV and HAdV in hospitalized patients with SARI, who aged ≤ 18 years in Tehran, Iran. Materials and Methods: To detect these two viruses, a conventional nested RT-PCR (Reverse transcription-polymerase chain reaction) assay was performed on 264 throat swabs collected from December 2018 to March 2019. The epidemiological data were analyzed and phylogenetic trees were constructed. Results: Of 264 cases with SARI, 36 (13.6%) and 28 (10.6%) were positive for HAdV and HRV respectively. Of 21 HRV sequenced samples, HRV-A (42.9%), HRV-B (9.5%) and HRV-C (47.6%) and of 36 HAdV sequenced samples, HAdV-C6 (38.9%), HAdV-B7 (22.2%), HAdV-B3 (11.1%), HAdV-B16 (5.6%), HAdV-C5 (13.9%), HAdV-C57 (5.6%), HAdV-E4 (2.8%); were detected in children with SARI. Some viral genotypes appeared to cause more severe disease, which may lead to hospitalization. Conclusion: Large-scale studies are recommended to investigate the epidemiology and molecular characterizations through surveillance networks to provide useful information on etiology, seasonality, and demographic associations in patients with SARI.
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Abbasi et al. (2023) conducted a cross-sectional in Severe acute respiratory infection (SARI) (n=264). Human rhinoviruses (HRVs) and human adenoviruses (HAdVs) was evaluated on Detection and phylogenetic characterization of HRV and HAdV. Among 264 children hospitalized with severe acute respiratory infection, human adenoviruses and rhinoviruses were detected in 13.6% and 10.6% of cases, respectively.
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