What is the clinical evidence from this study?

Study design: Observational. Population: Acute Respiratory Illness (n=203). Intervention: Human Rhinovirus C (HRV-C) infection. Primary outcome: Febrile wheeze or asthma presentation.

September 6, 2007Journal of Clinical MicrobiologyOpen Access

Clinical Features and Complete Genome Characterization of a Distinct Human Rhinovirus (HRV) Genetic Cluster, Probably Representing a Previously Undetected HRV Species, HRV-C, Associated with Acute Respiratory Illness in Children

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Key result

A newly identified human rhinovirus species, HRV-C, was detected in 21 samples from hospitalized children and presented most commonly as febrile wheeze or asthma (76%).

Population

203 prospectively collected nasopharyngeal aspirates from hospitalized children during a 1-year period…

Design

Cross-sectional

Authors

SLSusanna K. P. LauDepartment of Health CYCyril Chik‐Yan YipChinese University of Hong Kong HTHoi‐Wah TsoiUniversity of Hong Kong

Discussion

Member takes

Implication

HRV-C may contribute to pediatric febrile wheeze; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=203)

Structured PICO

Population

203 hospitalized children with acute respiratory illness, whose nasopharyngeal aspirates were negative for common respiratory viruses, evaluated over a 1-year period.

Exposure

Reverse transcription-PCR for HRV and complete genome sequencing

Outcome

Detection and phylogenetic characterization of HRV strainssurrogate

Identifies a novel HRV species, HRV-C, as an important cause of febrile wheeze and asthmatic exacerbations in hospitalized children.

Cite This Study

Lau et al. (2007) conducted an observational in Acute Respiratory Illness (n=203). Human Rhinovirus C (HRV-C) infection was evaluated on Febrile wheeze or asthma presentation. A newly identified human rhinovirus species, HRV-C, was detected in 21 samples from hospitalized children and presented most commonly as febrile wheeze or asthma (76%).

synapsesocial.com/papers/6a6b6780050bc01bbbcb656b https://doi.org/10.1128/jcm.01254-07

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Clinical Features and Complete Genome Characterization of a Distinct Human Rhinovirus (HRV) Genetic Cluster, Probably Representing a Previously Undetected HRV Species, HRV-C, Associated with Acute Respiratory Illness in Children

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Clinical Features and Complete Genome Characterization of a Distinct Human Rhinovirus (HRV) Genetic Cluster, Probably Representing a Previously Undetected HRV Species, HRV-C, Associated with Acute Respiratory Illness in Children

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider