Key result
Hypoxia reduced and hyperoxia magnified the transient decrease in arterial pH during heavy exercise, demonstrating that carotid body chemosensitivity predominantly constrains variations in arterial pH.
Why the study?
What is the role of the carotid bodies in the respiratory compensation for the metabolic acidosis of exercise in humans?
Population
Human subjects
Comparison
Prolonged square-wave cycle ergometry at… vs Different inspired oxygen fractions compared…
Design
Other
Follow-up
24 minutes
Authors
Loading...
Carotid body modulation of ventilatory compensation during exercise acidosis is clarified experimentally; leaves open any clinical translation to acid-base disorders.
What is the role of the carotid bodies in the respiratory compensation for the metabolic acidosis of exercise in humans?
Carotid body chemosensitivity plays a dominant role in constraining variations of arterial pH in response to the acute metabolic acidosis of heavy exercise in humans.
Rausch et al. (1991) studied Exercise-induced metabolic acidosis. Varying inspired oxygen fractions vs. FI,O2 0.21 (normal carotid body gain) was evaluated on Arterial pH and ventilatory variables. Hypoxia reduced and hyperoxia magnified the transient decrease in arterial pH during heavy exercise, demonstrating that carotid body chemosensitivity predominantly constrains variations in arterial pH.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: