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The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, Bruick and McKnight1 detail new findings ( Lando et al .2) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated. 1: http://www.sciencemag.org/cgi/content/full/295/5556/807 2: http://www.sciencemag.org/cgi/content/short/295/5556/858
Bruick et al. (Fri,) studied this question.