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The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, [Bruick and McKnight][1] detail new findings ([ Lando et al .][2]) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated. [1]: http://www.sciencemag.org/cgi/content/full/295/5556/807 [2]: http://www.sciencemag.org/cgi/content/short/295/5556/858
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Bruick et al. (2002) studied this question.
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