The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, [Bruick and McKnight][1] detail new findings ([ Lando et al .][2]) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated. [1]: http://www.sciencemag.org/cgi/content/full/295/5556/807 [2]: http://www.sciencemag.org/cgi/content/short/295/5556/858
No takes yet. Share an insight, caveat, or question.
Bruick et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: