Association between the exercise ejection fraction response and systolic wall stress in patients with chronic aortic insufficiency.
Key result
A fall in exercise ejection fraction was associated with higher left ventricular end-systolic wall stress compared to an increase or no change (89 vs 70 and 69 x 10^3 dyne/cm2; p<0.005).
Why the study?
How does the exercise ejection fraction response correlate with systolic wall stress in patients with chronic aortic insufficiency?
Population
56 patients with chronic aortic insufficiency, left ventricular dilatation, preserved resting ejection…
Design
Cross-sectional
Authors
Discussion
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Implication
Hypothesis-generating for exercise EF in aortic insufficiency; prospective studies needed before clinical adoption.
Study Design
Type
Observational (n=56)
Structured PICO
How does the exercise ejection fraction response correlate with systolic wall stress in patients with chronic aortic insufficiency?
P
Population
56 patients with chronic aortic insufficiency, left ventricular dilatation, preserved resting ejection fraction, and minimal or no symptoms.
E
Exposure
Exercise testing
O
Outcome
Left ventricular end-systolic wall stress and end-systolic volume response to exercisesurrogate
Main Result
p-value: p=<0.005
In asymptomatic patients with chronic aortic insufficiency, a fall in ejection fraction during exercise is associated with higher resting left ventricular end-systolic wall stress and marked increases in end-systolic volume.
Limitations
- Stress could not be determined directly during exercise
Cite This Study
Greenberg et al. (1985) conducted an observational in Chronic aortic insufficiency (n=56). Fall in exercise ejection fraction vs. Increase or no change in exercise ejection fraction was evaluated on Left ventricular end-systolic wall stress (p=<0.005). A fall in exercise ejection fraction was associated with higher left ventricular end-systolic wall stress compared to an increase or no change (89 vs 70 and 69 x 10^3 dyne/cm2; p<0.005).