Key result
The MTHFR C667T rs1801133 polymorphism was significantly associated with an increased risk of H-type hypertension, whereas the A1298C rs1801131 polymorphism showed no significant correlation.
Why the study?
Epidemiological studies investigating the association between MTHFR polymorphisms and H-type hypertension had yielded inconsistent results.
Are MTHFR polymorphisms associated with an increased risk of H-type hypertension?
Population
1759 cases and 1581 controls across 14 studies
Comparison
MTHFR polymorphisms vs controls
Design
Systematic review and network meta-analysis of diagnostic test accuracy
Authors
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MTHFR C667T may inform risk stratification models for H-type hypertension; leaves open whether screening improves outcomes in prospective studies.
Meta-Analysis (n=3,340)
Are MTHFR polymorphisms associated with an increased risk of H-type hypertension?
The MTHFR C667T rs1801133 polymorphism is significantly associated with an increased risk of H-type hypertension and may serve as a predictive biomarker.
Kong et al. (2022) conducted a meta-analysis in H-type hypertension (n=3,340). MTHFR polymorphisms (C667T rs1801133 and A1298C rs1801131) vs. Controls was evaluated on H-type hypertension susceptibility. The MTHFR C667T rs1801133 polymorphism was significantly associated with an increased risk of H-type hypertension, whereas the A1298C rs1801131 polymorphism showed no significant correlation.