Key result
Dofetilide prolonged ventricular repolarization and refractory period without affecting afterload, preload, or cardiac conduction in an in vivo canine model.
Why the study?
Does dofetilide alter hemodynamic and electrophysiological parameters in an in vivo canine model?
Does dofetilide alter hemodynamic and electrophysiological parameters in an in vivo canine model?
In a canine model, dofetilide prolonged repolarization without adversely affecting ventricular preload, afterload, or cardiac conduction, supporting its safety in patients with left ventricular dysfunction.
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Dofetilide may reduce heart rate and prolong ventricular parameters at clinical doses in dogs; leaves open human translation.
Satoh et al. (1999) studied this question. Dofetilide was evaluated on Hemodynamic and electrophysiological parameters. Dofetilide prolonged ventricular repolarization and refractory period without affecting afterload, preload, or cardiac conduction in an in vivo canine model.
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