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This paper reviews the present state of the Reformatsky reaction, the advancement of which has recently led to a considerable extension of its scope. 1. Introduction 2. Reagent Structure and Reaction Mechanism 3. The Role of Metal Activation 4. Substitution of Zinc by Other Metals 5. Reactive Halogen Compounds: Precursors of Reformatsky Donor Reagents 5.1. α-Halo Carbonyl Compounds 5.2. Stereoselectivity in Reformatsky Reactions 5.3. Alkyl 2-Bromomethyl-2-alkenoates and Heteroanalogues 5.4. Alkyl 4-Bromo-2-alkenoates 5.5. Zinc Homocnolates 6. Electrophiles in Reformatsky Reactions 6.1. Carbonyl Compounds and Derivatives, Intermolecular Reactions 6.2. Intramolecular Reformatsky Reactions 6.3. Uncommon Electrophiles in Reformatsky Reactions 7. Conclusions and Outlook
Alois Fürstner (Sun,) studied this question.