What question did this study set out to answer?

The study aims to investigate the presence and function of cytochrome b-245 in patients with chronic granulomatous disease.

Absence of Cytochrome b-245in Chronic Granulomatous Disease

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Randomized trial measures cytochrome levels in patients with chronic granulomatous disease, suggesting a causal link.

The study aims to investigate the presence and function of cytochrome b-245 in patients with chronic granulomatous disease.
Measured cytochrome levels in granulocytes from 27 patients and 64 family members.
Assessed X chromosome location of the genetic defect in men.
Examined functional properties of cytochrome in patients with probable autosomal recessive inheritance.
Cytochrome b-245 was undetectable in all 19 male patients with an X-linked defect.
Heterozygous female carriers showed reduced cytochrome concentrations and variable superoxide generation (r = 0.93, P < 0.001).
In 8 patients with probable autosomal recessive inheritance, cytochrome was present but nonfunctional.

Segal et al. (1983) studied this question.

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