Key result
Molecular pathways of aging, including oxidative stress, p66(Shc), sirtuins, GDF11, and telomere length, contribute to cardiovascular and cerebrovascular diseases and offer novel therapeutic targets.
Understanding the molecular pathways of vascular aging, including oxidative stress and sirtuins, may lead to novel therapeutic targets for age-related cardiovascular diseases.
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May guide aging-targeted CVD therapies; leaves open clinical validation in prospective trials.
Camici et al. (2015) conducted a review in Cardiovascular and cerebrovascular diseases. Molecular pathways of aging, including oxidative stress, p66(Shc), sirtuins, GDF11, and telomere length, contribute to cardiovascular and cerebrovascular diseases and offer novel therapeutic targets.
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