Key result
Four of five endogenous murine leukemia virus LTRs contained a highly conserved 190-base-pair insert bounded by 6-bp direct repeats, which was absent from ecotropic or xenotropic proviruses.
Population
NFS-Th-1 xenotropic murine leukemia virus DNA and five endogenous proviruses cloned from BALB/c mouse…
Design
Preclinical
Authors
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Conserved LTR elements in endogenous MuLV leave open transcriptional regulation roles; functional validation required before any translational consideration.
Endogenous murine leukemia proviral LTRs contain a unique 190-bp insert not found in ecotropic or xenotropic proviruses, providing insights into their evolutionary divergence.
Khan et al. (1983) studied Murine leukemia virus. Four of five endogenous murine leukemia virus LTRs contained a highly conserved 190-base-pair insert bounded by 6-bp direct repeats, which was absent from ecotropic or xenotropic proviruses.
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