Key result
Troponin I assessment at 24 hours strongly correlated with new myocyte necrosis (r=0.83, P<0.001) and predicted type V MI with 88% sensitivity and 97% specificity, outperforming CK-MB.
Why the study?
Do cardiac biomarkers (Troponin I and CK-MB) accurately diagnose type V myocardial infarction after CABG compared to cardiac MRI?
Population
40 patients undergoing coronary artery bypass grafting (CABG) included in a single-centre randomised trial
Comparison
Assessment of cardiac biomarkers vs Delayed enhancement cardiac magnetic resonance…
Design
Cohort, null, null
Follow-up
24 hours
Authors
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TnI at 24 hours may aid type V MI diagnosis after CABG; leaves open whether it replaces CMR or guideline thresholds.
RCT (n=40)
No
Do cardiac biomarkers (Troponin I and CK-MB) accurately diagnose type V myocardial infarction after CABG compared to cardiac MRI?
Effect estimate: r = 0.83
p-value: p=<0.001
Troponin I alone at 24 hours is highly accurate for detecting type V myocardial infarction after CABG, potentially challenging the need for supplementary evidence required by current guidelines.
Pegg et al. (2011) conducted an RCT in Type V myocardial infarction after CABG (n=40). Troponin I (TnI) vs. Creatine kinase-MB (CK-MB) was evaluated on Mass of new myocyte necrosis as assessed by DE-CMR (r = 0.83, p=<0.001). Troponin I assessment at 24 hours strongly correlated with new myocyte necrosis (r=0.83, P<0.001) and predicted type V MI with 88% sensitivity and 97% specificity, outperforming CK-MB.
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