Key result
Among 62 infants tested for suspected Parechovirus A infection in Queensland during the 2013-2014 summer, 25 were positive, and all 23 typable samples were identified as HPeV-3.
Observational (n=62)
HPeV-3 was the predominant genotype among ill infants in Queensland during the 2013-2014 summer, suggesting HPeV screening should be considered for acutely ill young infants with CNS-related symptoms.
HPeV-3 predominated in this Queensland infant cohort; hypothesis-generating for targeted screening, pending prospective outcome data.
Parechoviruses (HPeV) are not new viruses and are found in the respiratory tract and central nervous system of children and adults in conjunction with a range of acute illnesses. During an Australian outbreak of HPeV in the summer of 2013, we performed PCR-based screening and genotyping to determine whether ill Queensland infants were infected by HPeV. HPeVs were detected among 25/62 samples, identified as HPeV-3 from 23 that could be genotyped. These variants closely matched those occurring during and after the 2013 HPeV season. The inclusion of HPeV screening should be considered among acutely ill young infants during summer. Highlights HPeV-3 was the most common Parechovirus A genotype in Queensland summer of 2013/14 HPeV testing should be routine among testing of infants with acute CNS - related symptoms HPeV is a seasonal virus Subgenomic phylogenetic analysis of HPeVs can be confounded by the presence of recombination
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McNeale et al. (2017) conducted an observational in Suspected Parechovirus A infection (n=62). Parechovirus A infection was evaluated on HPeV positivity and genotype identification. Among 62 infants tested for suspected Parechovirus A infection in Queensland during the 2013-2014 summer, 25 were positive, and all 23 typable samples were identified as HPeV-3.
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