Key result
The 2015 outbreak of severe infections in Australian infants was caused by a novel recombinant strain of human parechovirus type 3, which was 98.7% similar to the Yamagata 2011 lineage in the structural region but highly divergent downstream.
Observational (n=16)
No
The 2015 HPeV3 outbreak in Australian infants was caused by a novel recombinant strain with a highly conserved capsid region, suggesting potential for vaccine or antibody treatment development.
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Alerts clinicians to recombinant parechovirus threats in infants; leaves open conserved capsid for vaccine or antibody development.
Nelson et al. (2017) conducted an observational in Human parechovirus type 3 (HPeV3) infection (n=16). Novel recombinant strain of human parechovirus type 3 (HPeV3) was evaluated on Genomic sequence similarity and recombination analysis. The 2015 outbreak of severe infections in Australian infants was caused by a novel recombinant strain of human parechovirus type 3, which was 98.7% similar to the Yamagata 2011 lineage in the structural region but highly divergent downstream.
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