Key result
Being a secondborn child was associated with a nearly 9-fold increased risk of contracting HPeV-3 infections compared with firstborn children (IRR 8.68; 95% CI 3.85-19.53).
Why the study?
Does having an older sibling increase the risk of severe human parechovirus infections in infants?
Cohort (n=132)
Yes
Does having an older sibling increase the risk of severe human parechovirus infections in infants?
Relative Risk: 8.68 (95% CI 3.85–19.53)
Having a slightly older sibling significantly increases the risk for severe neonatal HPeV-3 infections, suggesting a potential target for preventive measures.
Authors
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May inform HPeV-3 risk assessment by birth order; leaves open whether sibling-targeted prevention is effective.
Nielsen et al. (2016) conducted a cohort in Human parechovirus (HPeV) infections (n=132). Being a secondborn child (having an older sibling) vs. Firstborn children was evaluated on Contracting HPeV-3 infections (IRR 8.68, 95% CI 3.85-19.53). Being a secondborn child was associated with a nearly 9-fold increased risk of contracting HPeV-3 infections compared with firstborn children (IRR 8.68; 95% CI 3.85-19.53).
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