Why the study?
Does HPeV-specific PCR testing increase the detection of viral causes of sepsis-like illness and meningitis in children aged <5 years compared to EV-specific PCR alone?
Population
716 children aged <5 years with cerebrospinal fluid samples previously tested by EV-specific PCR during…
Comparison
HPeV-specific real-time PCR testing vs EV-specific PCR testing
Design
Cohort
Authors
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May support adding HPeV PCR to EV testing in neonates; leaves open impact on management or outcomes.
Does HPeV-specific PCR testing increase the detection of viral causes of sepsis-like illness and meningitis in children aged <5 years compared to EV-specific PCR alone?
Adding HPeV-specific PCR to routine EV testing significantly increases the identification of viral causes for sepsis-like illness and meningitis in young children, potentially reducing unnecessary antibiotic use and hospital stays.
Wolthers et al. (2008) studied this question.
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