Key result
Human parechovirus 1 utilizes alpha(V) and beta(3) integrins for attachment and enters host cells via the clathrin-dependent endocytic pathway.
Population
Host cells infected with Human parechovirus 1 (HPEV-1) in vitro
Design
Preclinical
Authors
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May guide antiviral target development; leaves open human relevance and clinical translation.
HPEV-1 enters host cells via a clathrin-dependent endocytic pathway, utilizing alpha(V) and beta(3) integrins as receptors.
Joki‐Korpela et al. (2001) studied Human parechovirus 1 (HPEV-1) infection. Antibodies against alpha(V) and beta(3) integrin subunits was evaluated on Viral entry mechanisms (attachment and internalization). Human parechovirus 1 utilizes alpha(V) and beta(3) integrins for attachment and enters host cells via the clathrin-dependent endocytic pathway.
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