Key result
Diabetes is linked to ~23 percentage points higher prevalence of radial artery atherosclerotic plaques.
Why the study?
Prediabetes and diabetes mellitus are common in acute coronary syndrome patients, but the association between diabetes status and radial artery atherosclerosis assessed by optical coherence tomography required evaluation.
Does diabetes or prediabetes alter the structural characteristics and increase atherosclerosis of the radial artery in patients with acute coronary syndrome?
Cross-Sectional (n=335)
No
Does diabetes or prediabetes alter the structural characteristics and increase atherosclerosis of the radial artery in patients with acute coronary syndrome?
Radial artery atherosclerosis and structural abnormalities are significantly increased in patients with both prediabetes and diabetes, which may impact the suitability of the radial artery as a bypass conduit.
Answers are grounded in this paper and cite their sources.
Radial plaques more frequent with diabetes/prediabetes in ACS; hypothesis-generating association that should not yet change conduit selection.
Background Prediabetes (PDM) and diabetes mellitus (DM) are common among acute coronary syndrome (ACS) patients. The present study evaluated the association between diabetes status and radial artery (RA) atherosclerosis using optical coherence tomography (OCT) in ACS patients. Methods A total of 335 ACS patients who underwent RA OCT were categorized into the DM group, the PDM group, and the normal glucose metabolism (NGM) group. OCT characteristics and clinical variables were compared. Results RA atherosclerotic plaques were more frequent in the PDM and DM groups than in the NGM group (38.7% vs. 33.3% vs. 16.1%, p = 0.001). Lipid and calcified plaque occurrence were significantly more common in the DM group, followed by the PDM and NGM groups (19.3% vs. 14.6% vs. 6.5%, p = 0.027; 11.8% vs. 6.5% vs. 1.1%, p = 0.009). The prevalence of microvessels in the PDM group was significantly higher (42.7% vs 23.7%, p = 0.017) than in the NGM group but was comparable to the DM group. Multivariate analysis revealed that HbA1c level and age were independent predictors of RA plaque formation and eccentric intimal hyperplasia (all p<0.05). Conclusions RA atherosclerosis characteristics differ according to diabetes status. HbA1c level could be a useful marker for RA atherosclerosis progression in ACS patients.
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Li et al. (2022) conducted a cross-sectional in Acute coronary syndrome (ACS) (n=335). Diabetes mellitus and prediabetes vs. Normal glucose metabolism was evaluated on Radial artery atherosclerotic plaque frequency (p=0.001). Radial artery atherosclerotic plaques were significantly more frequent in patients with diabetes (38.7%) and prediabetes (33.3%) compared to those with normal glucose metabolism (16.1%).
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