Key result
Prediabetes and diabetes were associated with similarly reduced coronary artery diameters compared to normal glucose tolerance in patients with first-diagnosed acute coronary syndrome, with the left main coronary artery being the most affected segment (p<0.001).
Why the study?
Coronary artery diameters are widely affected by more severe and widespread atherosclerosis in diabetic patients, but this has not been evaluated in prediabetics.
Does prediabetes reduce coronary artery diameters similarly to diabetes in patients with first diagnosis acute coronary syndrome?
Cross-Sectional (n=266)
Blinded assessors
No
Does prediabetes reduce coronary artery diameters similarly to diabetes in patients with first diagnosis acute coronary syndrome?
Prediabetes is associated with significantly reduced coronary artery diameters and increased coronary atherosclerosis severity, similar to overt diabetes, in patients presenting with their first acute coronary syndrome.
Answers are grounded in this paper and cite their sources.
Prediabetes may merit equivalent risk consideration to diabetes in ACS; leaves open causal effects on vessel diameters.
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Özen et al. (2022) conducted a cross-sectional in Acute coronary syndrome (n=266). Prediabetes and Diabetes (Elevated HbA1c) vs. Normal HbA1c (<5.7%) was evaluated on Left main coronary artery (LMCA) diameter (mm) (p=<0.001). Prediabetes and diabetes were associated with similarly reduced coronary artery diameters compared to normal glucose tolerance in patients with first-diagnosed acute coronary syndrome, with the left main coronary artery being the most affected segment (p<0.001).
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