Key result
Diabetes mellitus was associated with more extensive coronary artery disease compared to nondiabetics (mean 2.2 vs 1.8 vessels affected, p<0.01).
Why the study?
Does diabetes mellitus affect the angiographic severity and distribution of coronary artery disease compared to nondiabetic patients?
RCT (n=673)
Randomized
Does diabetes mellitus affect the angiographic severity and distribution of coronary artery disease compared to nondiabetic patients?
Absolute Event Rate: 2.2% vs 1.8%
p-value: p=<0.01
Diabetic patients exhibit more diffuse and severe angiographic coronary artery disease compared to matched nondiabetic patients, with no sex-related differences in severity among diabetics.
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Should not change practice; leaves open prognostic and therapeutic implications of diabetes-associated CAD extent.
Melidonis et al. (1999) conducted an RCT in Coronary artery disease (n=673). Diabetes mellitus vs. Nondiabetic patients was evaluated on Extent of coronary artery disease (mean number of vessels affected) (p=<0.01). Diabetes mellitus was associated with more extensive coronary artery disease compared to nondiabetics (mean 2.2 vs 1.8 vessels affected, p<0.01).
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