Key result
Diabetes mellitus was associated with a significantly higher incidence of multivessel coronary artery disease (42.1% vs 19.6%) compared to non-diabetic patients.
Why the study?
Coronary artery disease is one of the most important manifestations of diabetes mellitus, motivating assessment of the extent of CAD in diabetic versus non-diabetic patients undergoing coronary angiography.
Does diabetes mellitus increase the severity and extent of coronary artery disease in patients undergoing coronary angiography?
Cross-Sectional (n=793)
No
Does diabetes mellitus increase the severity and extent of coronary artery disease in patients undergoing coronary angiography?
Absolute Event Rate: 42.1% vs 19.6%
p-value: p=<0.001
Diabetic patients with suspected CAD have significantly more severe and extensive angiographic disease, including higher rates of triple vessel disease, compared to non-diabetics.
May inform risk stratification in diabetics referred for angiography; hypothesis-generating and should not yet change practice.
Background: Coronary artery disease (CAD) is one of the most important manifestation of diabetes mellitus. Objectives: To assess the extent of CAD in diabetic and non diabetic patients undergoing coronary angiography. Materials and Methods: 793 patients with suspected CAD, 202 diabetics and 591 non-diabetics were enrolled in the study. All patients underwent coronary angiography. Results: Normal coronaries were more common in non diabetic patients. Age at first presentation in diabetics was earlier as compared to non-diabetics. Diabetic female patients presented as early as third decade of life. Single vessel involvement was significantly more in non diabetics [40.27%] as compared to diabetic patients[19.8%][P= <0.001], while there were statistically no significant differences in double vessel disease in both groups [P= 0.572]. Triple vessel disease were more common in diabetic than non diabetic patients [P= <0.001]. Left main disease, left circumflex coronary artery disease, coronary calcification, diffuse disease and CTOs were more common in diabetic patients. Conclusion: The severity and extent of CAD and incidence of triple vessel disease was significantly high in diabetics when compared to non diabetics.
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Sharma et al. (2019) conducted a cross-sectional in Coronary artery disease (n=793). Diabetes mellitus vs. Non-diabetic patients was evaluated on Incidence of multivessel disease (p=<0.001). Diabetes mellitus was associated with a significantly higher incidence of multivessel coronary artery disease (42.1% vs 19.6%) compared to non-diabetic patients.
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