Key result
Observational and epidemiological studies, including Mendelian randomization, provide essential insights into the long-term determinants, prevention, and treatment of mental illness in older adults.
Why the study?
Randomised controlled clinical trials face high costs precluding long-term or large-population studies as well as ethical constraints, highlighting the value of observational epidemiological research.
Observational studies and epidemiological advances provide valuable alternatives to RCTs for studying long-term effects and population-wide trends in older adult psychiatry.
May guide long-term strategies in older adult psychiatry where RCTs are scarce; extends evidence base but leaves causal questions open.
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Shoham et al. (2020) conducted an editorial in Mental illness in old age. Observational and epidemiological studies, including Mendelian randomization, provide essential insights into the long-term determinants, prevention, and treatment of mental illness in older adults.
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