What does this research mean for the field?

Sixteen weeks of exercise training counteracts the impairment of skeletal muscle mitochondrial function induced by energy restriction in older adults with prediabetes and metabolic syndrome, with some sex-specific differences in the response. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This trial aims to assess whether exercise training can reverse mitochondrial function impairment caused by energy restriction in older prediabetics, considering sex differences.

November 27, 2024Scandinavian Journal of Medicine and Science in SportsOpen Access

Exercise Training Counteracts Compromised Mitochondrial Capacity Induced by Energy Restriction in Prediabetics in a Sex‐Dependent Manner

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Authors

MMMagni MohrUniversity of the Faroe Islands JAJerónimo Aragón‐VelaUniversidad de Jaén MSMay‐Britt SkoradalUniversity of the Faroe Islands

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Implication

Randomized trial examines exercise effects on mitochondrial function in prediabetics, suggesting sex-dependent responses.

Key Points

This trial aims to assess whether exercise training can reverse mitochondrial function impairment caused by energy restriction in older prediabetics, considering sex differences.
50 sedentary prediabetic individuals (age 55-70 years, both sexes) were randomized into exercise and dietary advice (EX-DI) or dietary advice only (DI).
Exercise training included 30-60 min sessions of recreational small-sided soccer over 16 weeks.
Maximal activity of mitochondrial enzymes and protein levels were measured pre- and post-intervention.
Dietary intervention alone decreased citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities by 18% and 23% respectively (p < 0.001).
Exercise training prevented dietary impairment of mitochondrial enzyme activities.
Maximal citrate synthase activity decreased only in men during both EX-DI and DI (all p < 0.05).

Cite This Study

Mohr et al. (2024) studied this question.

synapsesocial.com/papers/6a6b9156547974b2dbf454bb https://doi.org/10.1111/sms.14768

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Exercise Training Counteracts Compromised Mitochondrial Capacity Induced by Energy Restriction in Prediabetics in a Sex‐Dependent Manner

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Key Points

Cite This Study

Exercise Training Counteracts Compromised Mitochondrial Capacity Induced by Energy Restriction in Prediabetics in a Sex‐Dependent Manner

Discussion

Member takes

Implication

Key Points

Cite This Study

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