Key result
Daily injections of ANG-(1-7) significantly inhibited angiogenesis in the mouse sponge model compared to saline, an effect prevented by specific receptor antagonists and NO synthase inhibitors.
Population
Mouse sponge model of angiogenesis
Comparison
Daily injections of Angiotensin-, with or… vs Saline-treated group
Design
Preclinical
Follow-up
7 days
Authors
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ANG-(1-7) may inhibit angiogenesis via receptor/NO mechanisms in mice; leaves open clinical translation.
ANG-(1-7) inhibits angiogenesis via a novel angiotensin receptor and nitric oxide release, distinct from AT1 and AT2 pathways.
Machado et al. (2001) studied Angiogenesis. Angiotensin-(1-7) vs. Saline was evaluated on Hemoglobin content (microg/mg wet tissue) of 7-day-old sponge implants. Daily injections of ANG-(1-7) significantly inhibited angiogenesis in the mouse sponge model compared to saline, an effect prevented by specific receptor antagonists and NO synthase inhibitors.
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