Key result
The inotropic effect of extracellular calcium concentration changes is dependent on muscle length, with a substantially greater modification of force occurring at short lengths than at long lengths.
Population
21 isolated cat papillary muscles studied at temperatures of 30 degrees C and 32 degrees C, and rates of 12…
Comparison
Exposure to extracellular calcium concentrations… vs Comparison across different calcium…
Design
Preclinical
Authors
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Calcium alters force-length relations in isolated myocardium; leaves open clinical relevance for contractility modulation.
In isolated cat papillary muscles, the inotropic effect of extracellular calcium concentration is dependent on muscle length, with greater force modification occurring at shorter lengths.
Huntsman et al. (1977) studied this question. Extracellular calcium concentration was evaluated on Peak developed force and time from stimulus to peak. The inotropic effect of extracellular calcium concentration changes is dependent on muscle length, with a substantially greater modification of force occurring at short lengths than at long lengths.
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