Key result
Lower hs-CRP levels were associated with significantly higher heart rate variability, with a mean SDNN of 140 ms in the lowest quartile compared to 113 ms in the highest quartile.
Why the study?
Is C-reactive protein associated with heart rate variability in patients with suspected coronary heart disease?
Population
269 subjects referred for elective coronary angiography due to clinically suspected coronary heart disease…
Design
Cross-sectional
Authors
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Low-grade inflammation-autonomic links in angiography referrals need prospective validation; leaves open SCD risk prediction utility.
Cross-Sectional (n=269)
No
Is C-reactive protein associated with heart rate variability in patients with suspected coronary heart disease?
Absolute Event Rate: 140% vs 113%
p-value: p=<0.001
Elevated C-reactive protein is independently associated with reduced heart rate variability in patients with suspected coronary heart disease, suggesting a link between low-grade inflammation and autonomic dysfunction.
Madsen et al. (2007) conducted a cross-sectional in Clinically suspected coronary heart disease (n=269). Lower hs-CRP quartile vs. Upper hs-CRP quartile was evaluated on Mean SDNN (standard deviation of all N-N intervals) (p=<0.001). Lower hs-CRP levels were associated with significantly higher heart rate variability, with a mean SDNN of 140 ms in the lowest quartile compared to 113 ms in the highest quartile.
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