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January 1, 2003Journal of Biological ChemistryOpen Access

JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes

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Authors

FLFlorence LegendreNormandie UniversitéJDJayesh DudhiaRoyal Veterinary CollegeJPJean‐Pierre PujolUniversité de Caen Normandie

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Legendre et al. (2003) studied this question.

synapsesocial.com/papers/6a6b9c2547a1bfb288f333efhttps://doi.org/10.1074/jbc.m110773200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis1998 · 274 citations
  2. 2The Antiinflammatory Sesquiterpene Lactone Parthenolide Inhibits NF-κB by Targeting the IκB Kinase Complex1999 · 356 citations
  3. 3TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway1995 · 1,832 citations
  4. 4IL-6 is produced by osteoblasts and induces bone resorption.1990 · 1,135 citations