Key result
Addition of apoA-IV increased lipoprotein lipase activation in the presence of VLDL, achieving 100% of the activity measured in whole serum.
Why the study?
Does apolipoprotein A-IV modulate the activation of lipoprotein lipase by apolipoprotein C-II in vitro?
Population
In vitro models including triglyceride emulsions, TG-rich lipoproteins from an apoC-II deficient subject…
Comparison
Addition of apolipoprotein A-IV and other plasma… vs Absence of apoA-IV or other specific plasma…
Design
Preclinical
Authors
Loading...
ApoA-IV may aid apoC-II transfer for LPL activation; leaves open its clinical role in TG metabolism pending human studies.
Does apolipoprotein A-IV modulate the activation of lipoprotein lipase by apolipoprotein C-II in vitro?
Apolipoprotein A-IV increases lipoprotein lipase activation in the presence of lipoproteins, likely by facilitating the release of apoC-II from HDL or VLDL.
Goldberg et al. (1990) studied this question. apoA-IV vs. Absence of apoA-IV was evaluated on Lipoprotein lipase (LPL) activity. Addition of apoA-IV increased lipoprotein lipase activation in the presence of VLDL, achieving 100% of the activity measured in whole serum.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: