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November 5, 2010Biology of Sex DifferencesOpen Access

Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent

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Why the study?

Does 17β-oestradiol regulate renal ACE2 activity independently of sex chromosomes in mice?

Population

MF1 wild type mice, four core genotypes mice on MF1 background, and ACE2 null mice on C57BL/6 background…

Comparison

Gonadectomy with or without 17β-oestradiol… vs Sham-operated intact mice or gonadectomized mice…

Design

Preclinical

Follow-up

1 month

Key result

Renal ACE2 activity was significantly higher in male compared to female mice (18.1 vs 11.1 RFU/min/µg protein), a difference dependent on 17beta-oestradiol and independent of sex chromosomes.

Authors

JLJun LiuHJHong JiWZWei Zheng

Discussion

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Overview

Sex differences in renal ACE2 activity may guide sex-specific research; leaves open estrogen modulation effects in human cardiovascular disease.

Structured PICO

Does 17β-oestradiol regulate renal ACE2 activity independently of sex chromosomes in mice?

P
Population
Animal study using mouse models to investigate the separate effects of gonadal hormones and sex chromosomes on renal ACE2 activity.
E
Exposure
Gonadectomy with or without 17β-oestradiol (E2) treatment (0.5 mg/90 days pellet subcutaneously for 1 month).
C
Comparator
Sham-operated intact mice or gonadectomized mice without E2 treatment.
O
Outcome
Renal ACE2 activity measured by fluorogenic peptide substrate.surrogate

Main Result

Absolute Event Rate: 18.1% vs 11.1%

p-value: p=<0.0001

Sex differences in renal ACE2 activity in mice are driven by the suppressive effects of 17β-oestradiol rather than sex chromosome complement.

Limitations

  • Conducted in a mouse model without known mutations increasing disease susceptibility
  • Cannot rule out regulation by other factors associated with development and aging
  • Did not investigate pathological conditions

Cite This Study

Liu et al. (2010) studied Sex differences in renal ACE2 activity. Male sex / 17beta-oestradiol vs. Female sex / Gonadectomy was evaluated on Renal ACE2 activity (RFU/min/µg protein) (p=<0.0001). Renal ACE2 activity was significantly higher in male compared to female mice (18.1 vs 11.1 RFU/min/µg protein), a difference dependent on 17beta-oestradiol and independent of sex chromosomes.

synapsesocial.com/papers/6a6ba08c78a09e5ab7b3b13fhttps://doi.org/10.1186/2042-6410-1-6
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