October 1, 1995Journal of Clinical Oncology
Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP versus CNOP chemotherapy.
Key result
CHOP chemotherapy resulted in a significantly higher overall complete response rate (49% vs 31%, P=0.03) and better 3-year survival (42% vs 26%) compared to CNOP in elderly patients with advanced NHL.
Why the study?
Does CHOP chemotherapy improve complete response and survival compared to CNOP in elderly patients with advanced non-Hodgkin's lymphoma?
Population
157 enrolled patients, elderly with advanced non-Hodgkin's lymphoma of intermediate- and high-grade…
Comparison
CHOP chemotherapy vs CNOP chemotherapy
Design
RCT, randomized
Follow-up
3 years
Authors
Discussion
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Implication
CHOP linked to higher CR and survival than CNOP in elderly advanced NHL; leaves open optimal modern regimens.
Study Design
Type
RCT (n=157)
Multicenter
Yes
Structured PICO
Does CHOP chemotherapy improve complete response and survival compared to CNOP in elderly patients with advanced non-Hodgkin's lymphoma?
P
Population
157 elderly patients (≥60 years) with advanced intermediate- and high-grade non-Hodgkin's lymphoma, followed for up to 3 years.
I
Intervention
CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone)
C
Comparator
CNOP chemotherapy (cyclophosphamide, mitoxantrone, vincristine, and prednisone)
O
Outcome
Tolerance and efficacy (overall complete response rates and survival)hard clinical
Main Result
Absolute Event Rate: 49% vs 31%
p-value: p=0.03
Cite This Study
Sonneveld et al. (1995) conducted an RCT in Advanced non-Hodgkin's lymphoma (n=157). CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) vs. CNOP (mitoxantrone instead of doxorubicin) was evaluated on Overall complete response (CR) rate (p=0.03). CHOP chemotherapy resulted in a significantly higher overall complete response rate (49% vs 31%, P=0.03) and better 3-year survival (42% vs 26%) compared to CNOP in elderly patients with advanced NHL.