Key result
In perfused rabbit hearts, the base-line time-average sarcoplasmic reticulum free calcium concentration was 1.5 mM, which decreased by approximately 30% at the start of systole.
Population
Langendorff perfused rabbit hearts loaded with acetoxymethyl ester of 1,2-bisethane-N,N,N',N'-tetraacetic acid
Design
Preclinical
Authors
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In vitro SR calcium data from rabbit hearts warrant clinical caution; leaves open in vivo human translation and energy-state links.
19F NMR can be used to measure [Ca2+]SR in perfused rabbit hearts, revealing a 30% decrease at systole and heterogeneous responses to pharmacological agents.
Chen et al. (1996) studied Perfused rabbit heart (animal model) (n=13). 19F NMR measurement of [Ca2+]SR was evaluated on Base-line time-average [Ca2+]SR value. In perfused rabbit hearts, the base-line time-average sarcoplasmic reticulum free calcium concentration was 1.5 mM, which decreased by approximately 30% at the start of systole.
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